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HTLV1 Target gene Detail Information

> F12 Gene Search Result


Gene Information
Gene Name F12
Gene ID 2161
Gene Full Name coagulation factor XII
Gene Alias HAF; HAE3; HAEX
Transcripts ENSG00000131187
Virus HTLV1
Gene Type protein coding
HPA Location Info
HPA Protein Class Info Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins
Uniport_ID P00748
HGNC ID HGNC:3530
VEGA ID OTTHUMG00000163403
OMIM ID 610619
String ID 9606.ENSP00000253496
Drugbank ID BE0004672
PharmGKB ID PA161
Target gene [F12] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6001154 chr15 102 206 256 564 View
6001208 chr13 82 186 263 531 View
6001274 chr5 363 116 28 507 View
6001772 chr13 283 54 13 350 View
6001870 chr15 97 213 18 328 View
6002903 chr13 172 24 4 200 View
6003595 chr13 151 151 View
6005545 chr15 16 63 6 85 View
6007211 chr17 9 13 36 58 View
6007503 chr13 14 17 24 55 View
6010664 chr17 26 4 30 View
6012370 chr15 22 1 23 View
6012893 chr13 21 21 View
6017512 chr11 10 10 View
6018683 chr3 6 2 1 9 View
6021323 chr1 6 6 View
6021673 chr15 5 5 View
6022283 chr3 4 1 5 View
6024200 chr15 3 3 View
6026645 chr3 1 1 2 View
6030166 chr15 1 1 View
6030871 chr15 0 View
6032912 chr15 0 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of F12 expression and immune infiltrating cell level correlation result in HTLV1+ samples
F12 expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of F12 expression and immune infiltrating cell level correlation result in HTLV1+ samples
F12 expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of F12 expression and immune infiltrating cell level correlation result in HTLV1+ samples
F12 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).