HIV Target gene Detail Information

> EZH2 Gene Search Result

Gene Information

Gene Name	EZH2
Gene ID	2146
Gene Full Name	enhancer of zeste 2 polycomb repressive complex 2 subunit
Gene Alias	WVS; ENX1; KMT6; WVS2; ENX-1; EZH2b; KMT6A
Transcripts	ENSG00000106462
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;
HPA Protein Class Info	Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Gene Function	Suppressor gene & Oncogene
Uniport_ID	Q15910
HGNC ID	HGNC:3527
VEGA ID	OTTHUMG00000158973
OMIM ID	601573
String ID	9606.ENSP00000320147
Drugbank ID	BE0009508; BE0009562
PharmGKB ID	PA27939

Target gene [EZH2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4003029	chr7	7	64	1	72	View
4004093	chr7	23	13	13	49	View
4005580	chr7	27	3	1	31	View
4011112	chr7	5	2		7	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of EZH2 expression and immune infiltrating cell level correlation result in HIV+ samples
EZH2 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of EZH2 expression and immune infiltrating cell level correlation result in HIV+ samples
EZH2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).