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HPV Target gene Detail Information

> ETS2 Gene Search Result


Gene Information
Gene Name ETS2
Gene ID 2114
Gene Full Name ETS proto-oncogene 2, transcription factor
Gene Alias ETS2IT1
Transcripts ENSG00000157557
Virus HPV
Gene Type protein coding
HPA Location Info Nucleoplasm;Cytosol;Plasma membrane;
HPA Protein Class Info Predicted intracellular proteins, RAS pathway related proteins, Transcription factors
Gene Function Suppressor gene & Oncogene
Uniport_ID P15036
HGNC ID HGNC:3489
VEGA ID OTTHUMG00000090769
OMIM ID 164740
String ID 9606.ENSP00000353344
PharmGKB ID PA27903
Target gene [ETS2] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
5000335 chr21 199 84 14 297 View
5000397 chr21 184 46 4 234 View
5000434 chr21 171 35 4 210 View
5000435 chr21 171 34 4 209 View
5000570 chr21 26 76 31 133 View
5000603 chr21 107 13 2 122 View
5000609 chr21 59 50 12 121 View
5000616 chr21 50 56 13 119 View
5000627 chr21 94 19 2 115 View
5000649 chr21 96 12 2 110 View
5000657 chr21 91 17 1 109 View
5001390 chr21 35 1 36 View
5001414 chr21 32 1 2 35 View
5001627 chr21 27 27 View
5001741 chr21 9 10 5 24 View
5002223 chr21 14 14 View
5002302 chr21 13 13 View
5402601 chr21 8 19 1 28 View
5402602 chr21 13 13 View
5402603 chr21 26 77 31 134 View
5402604 chr21 79 32 5 116 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE140662 (GEO) Condyloma Acuminatum 8 Condyloma acuminata (HPV+)(5), Skin(3)
GSE65858 (GEO) Head and neck squamous cell carcinoma 270 Head and neck squamous cell carcinoma (EBV+)(73), Head and neck squamous cell carcinoma (EBV-)(197)
GSE40774 (GEO) Head and neck squamous cell carcinoma 134 Head and neck Squamous cell carcinomas GLOTTIC LARYNX (EBV-)(2), Head and neck Squamous cell carcinomas HYPOPHARYNX (EBV-)(9), Head and neck Squamous cell carcinomas ORAL CAVITY (EBV-)(23), Head and neck Squamous cell carcinomas ORAL CAVITY (EBV+)(2), Head and neck Squamous cell carcinomas OROPHARYNX (EBV-)(22), Head and neck Squamous cell carcinomas OROPHARYNX (EBV+)(54), Head and neck Squamous cell carcinomas OTHER (EBV+)(1), Head and neck Squamous cell carcinomas SUBGLOTTIC LARYNX (EBV-)(1), Head and neck Squamous cell carcinomas SUPRAGLOTTIC (EBV-)(19), Squamous cell carcinomas SUPRAGLOTTIC (EBV+)(1)
GSE55546 (GEO) Oropharyngeal squamous cell carcinoma 16 Oropharyngeal cancers (HPV+)(12), Normal (4)
GSE55544 (GEO) Oropharyngeal squamous cell carcinoma 23 Oropharyngeal cancers HPV Active (11), Oropharyngeal cancers HPV Inactive (4), Oropharyngeal cancers HPV Negative (8)
GSE55542 (GEO) Oropharyngeal squamous cell carcinoma 36 Oropharyngeal cancers HPV Active (12), Oropharyngeal cancers HPV Inactive (8), Oropharyngeal cancers HPV Negative (16)
GSE138080 (GEO) Cervical intraepithelial neoplasia 25 Normal (10), Cervical intraepithelial neoplasia (HPV+)(15)
GSE51993 (GEO) Cervical intraepithelial neoplasia 24 Cervical intraepithelial neoplasia (HPV+)(17), Normal(7)
HNSC (TCGA) Head and Neck squamous cell carcinoma 566 Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE140662

HeatMap of cell type fractions in all samples Lollipop of ETS2 expression and immune infiltrating cell level correlation result in HPV+ samples
ETS2 expression: Low -> High

> Dataset: GSE65858

HeatMap of cell type fractions in all samples Lollipop of ETS2 expression and immune infiltrating cell level correlation result in HPV+ samples
ETS2 expression: Low -> High

> Dataset: GSE40774

HeatMap of cell type fractions in all samples Lollipop of ETS2 expression and immune infiltrating cell level correlation result in HPV+ samples
ETS2 expression: Low -> High

> Dataset: GSE55546

HeatMap of cell type fractions in all samples Lollipop of ETS2 expression and immune infiltrating cell level correlation result in HPV+ samples
ETS2 expression: Low -> High

> Dataset: GSE55544

HeatMap of cell type fractions in all samples Lollipop of ETS2 expression and immune infiltrating cell level correlation result in HPV+ samples
ETS2 expression: Low -> High

> Dataset: GSE55542

HeatMap of cell type fractions in all samples Lollipop of ETS2 expression and immune infiltrating cell level correlation result in HPV+ samples
ETS2 expression: Low -> High

> Dataset: GSE138080

HeatMap of cell type fractions in all samples Lollipop of ETS2 expression and immune infiltrating cell level correlation result in HPV+ samples
ETS2 expression: Low -> High

> Dataset: GSE51993

HeatMap of cell type fractions in all samples Lollipop of ETS2 expression and immune infiltrating cell level correlation result in HPV+ samples
ETS2 expression: Low -> High

> Dataset: HNSC

HeatMap of cell type fractions in all samples Lollipop of ETS2 expression and immune infiltrating cell level correlation result in HPV+ samples
ETS2 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).