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HPV Target gene Detail Information

> ESR2 Gene Search Result


Gene Information
Gene Name ESR2
Gene ID 2100
Gene Full Name estrogen receptor 2
Gene Alias Erb; ESRB; ESTRB; NR3A2; ER-BETA; ESR-BETA
Transcripts ENSG00000140009
Virus HPV
Gene Type protein coding
HPA Location Info
HPA Protein Class Info Cancer-related genes, FDA approved drug targets, Nuclear receptors, Predicted intracellular proteins, Transcription factors
Gene Function Suppressor gene
Uniport_ID Q92731
HGNC ID HGNC:3468
VEGA ID OTTHUMG00000141306
OMIM ID 601663
String ID 9606.ENSP00000343925
Drugbank ID BE0000792
PharmGKB ID PA27886
Target gene [ESR2] related to virus gene/protein/region
ID PMID Mutation Gene/Protein/Region Description Detail
1 29695285 A7793G
LCR
G
R
S
C
 View
2 32677948 A7376G
LCR
G
C
 View
3 32677948 T7791A
LCR
G
C
 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE140662 (GEO) Condyloma Acuminatum 8 Condyloma acuminata (HPV+)(5), Skin(3)
GSE65858 (GEO) Head and neck squamous cell carcinoma 270 Head and neck squamous cell carcinoma (EBV+)(73), Head and neck squamous cell carcinoma (EBV-)(197)
GSE55546 (GEO) Oropharyngeal squamous cell carcinoma 16 Oropharyngeal cancers (HPV+)(12), Normal (4)
GSE55544 (GEO) Oropharyngeal squamous cell carcinoma 23 Oropharyngeal cancers HPV Active (11), Oropharyngeal cancers HPV Inactive (4), Oropharyngeal cancers HPV Negative (8)
GSE55542 (GEO) Oropharyngeal squamous cell carcinoma 36 Oropharyngeal cancers HPV Active (12), Oropharyngeal cancers HPV Inactive (8), Oropharyngeal cancers HPV Negative (16)
GSE51993 (GEO) Cervical intraepithelial neoplasia 24 Cervical intraepithelial neoplasia (HPV+)(17), Normal(7)
HNSC (TCGA) Head and Neck squamous cell carcinoma 566 Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE140662

HeatMap of cell type fractions in all samples Lollipop of ESR2 expression and immune infiltrating cell level correlation result in HPV+ samples
ESR2 expression: Low -> High

> Dataset: GSE65858

HeatMap of cell type fractions in all samples Lollipop of ESR2 expression and immune infiltrating cell level correlation result in HPV+ samples
ESR2 expression: Low -> High

> Dataset: GSE55546

HeatMap of cell type fractions in all samples Lollipop of ESR2 expression and immune infiltrating cell level correlation result in HPV+ samples
ESR2 expression: Low -> High

> Dataset: GSE55544

HeatMap of cell type fractions in all samples Lollipop of ESR2 expression and immune infiltrating cell level correlation result in HPV+ samples
ESR2 expression: Low -> High

> Dataset: GSE55542

HeatMap of cell type fractions in all samples Lollipop of ESR2 expression and immune infiltrating cell level correlation result in HPV+ samples
ESR2 expression: Low -> High

> Dataset: GSE51993

HeatMap of cell type fractions in all samples Lollipop of ESR2 expression and immune infiltrating cell level correlation result in HPV+ samples
ESR2 expression: Low -> High

> Dataset: HNSC

HeatMap of cell type fractions in all samples Lollipop of ESR2 expression and immune infiltrating cell level correlation result in HPV+ samples
ESR2 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).