HTLV1 Target gene Detail Information

> ESAM Gene Search Result

Gene Information

Gene Name	ESAM
Gene ID	90952
Gene Full Name	endothelial cell adhesion molecule
Gene Alias	W117m
Transcripts	ENSG00000149564
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Microtubules;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Plasma proteins, Predicted membrane proteins
Uniport_ID	Q96AP7
HGNC ID	HGNC:17474
VEGA ID	OTTHUMG00000151986
OMIM ID	614281
String ID	9606.ENSP00000278927
PharmGKB ID	PA134954912

Target gene [ESAM] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6020940	chr11	6			6	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of ESAM expression and immune infiltrating cell level correlation result in HTLV1+ samples
ESAM expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of ESAM expression and immune infiltrating cell level correlation result in HTLV1+ samples
ESAM expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of ESAM expression and immune infiltrating cell level correlation result in HTLV1+ samples
ESAM expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).