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HPV Target gene Detail Information

> ERCC4 Gene Search Result


Gene Information
Gene Name ERCC4
Gene ID 2072
Gene Full Name ERCC excision repair 4, endonuclease catalytic subunit
Gene Alias XPF; RAD1; FANCQ; XFEPS; ERCC11
Transcripts ENSG00000175595
Virus HPV
Gene Type protein coding
HPA Location Info Nuclear bodies;Nucleoplasm;Plasma membrane;
HPA Protein Class Info Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins
Uniport_ID Q92889
HGNC ID HGNC:3436
VEGA ID OTTHUMG00000048194
OMIM ID 133520
String ID 9606.ENSP00000310520
PharmGKB ID PA27850
Target gene [ERCC4] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
5403322 chr16 23 1 24 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE140662 (GEO) Condyloma Acuminatum 8 Condyloma acuminata (HPV+)(5), Skin(3)
GSE65858 (GEO) Head and neck squamous cell carcinoma 270 Head and neck squamous cell carcinoma (EBV+)(73), Head and neck squamous cell carcinoma (EBV-)(197)
GSE40774 (GEO) Head and neck squamous cell carcinoma 134 Head and neck Squamous cell carcinomas GLOTTIC LARYNX (EBV-)(2), Head and neck Squamous cell carcinomas HYPOPHARYNX (EBV-)(9), Head and neck Squamous cell carcinomas ORAL CAVITY (EBV-)(23), Head and neck Squamous cell carcinomas ORAL CAVITY (EBV+)(2), Head and neck Squamous cell carcinomas OROPHARYNX (EBV-)(22), Head and neck Squamous cell carcinomas OROPHARYNX (EBV+)(54), Head and neck Squamous cell carcinomas OTHER (EBV+)(1), Head and neck Squamous cell carcinomas SUBGLOTTIC LARYNX (EBV-)(1), Head and neck Squamous cell carcinomas SUPRAGLOTTIC (EBV-)(19), Squamous cell carcinomas SUPRAGLOTTIC (EBV+)(1)
GSE55546 (GEO) Oropharyngeal squamous cell carcinoma 16 Oropharyngeal cancers (HPV+)(12), Normal (4)
GSE55544 (GEO) Oropharyngeal squamous cell carcinoma 23 Oropharyngeal cancers HPV Active (11), Oropharyngeal cancers HPV Inactive (4), Oropharyngeal cancers HPV Negative (8)
GSE55542 (GEO) Oropharyngeal squamous cell carcinoma 36 Oropharyngeal cancers HPV Active (12), Oropharyngeal cancers HPV Inactive (8), Oropharyngeal cancers HPV Negative (16)
GSE138080 (GEO) Cervical intraepithelial neoplasia 25 Normal (10), Cervical intraepithelial neoplasia (HPV+)(15)
GSE51993 (GEO) Cervical intraepithelial neoplasia 24 Cervical intraepithelial neoplasia (HPV+)(17), Normal(7)
HNSC (TCGA) Head and Neck squamous cell carcinoma 566 Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE140662

HeatMap of cell type fractions in all samples Lollipop of ERCC4 expression and immune infiltrating cell level correlation result in HPV+ samples
ERCC4 expression: Low -> High

> Dataset: GSE65858

HeatMap of cell type fractions in all samples Lollipop of ERCC4 expression and immune infiltrating cell level correlation result in HPV+ samples
ERCC4 expression: Low -> High

> Dataset: GSE40774

HeatMap of cell type fractions in all samples Lollipop of ERCC4 expression and immune infiltrating cell level correlation result in HPV+ samples
ERCC4 expression: Low -> High

> Dataset: GSE55546

HeatMap of cell type fractions in all samples Lollipop of ERCC4 expression and immune infiltrating cell level correlation result in HPV+ samples
ERCC4 expression: Low -> High

> Dataset: GSE55544

HeatMap of cell type fractions in all samples Lollipop of ERCC4 expression and immune infiltrating cell level correlation result in HPV+ samples
ERCC4 expression: Low -> High

> Dataset: GSE55542

HeatMap of cell type fractions in all samples Lollipop of ERCC4 expression and immune infiltrating cell level correlation result in HPV+ samples
ERCC4 expression: Low -> High

> Dataset: GSE138080

HeatMap of cell type fractions in all samples Lollipop of ERCC4 expression and immune infiltrating cell level correlation result in HPV+ samples
ERCC4 expression: Low -> High

> Dataset: GSE51993

HeatMap of cell type fractions in all samples Lollipop of ERCC4 expression and immune infiltrating cell level correlation result in HPV+ samples
ERCC4 expression: Low -> High

> Dataset: HNSC

HeatMap of cell type fractions in all samples Lollipop of ERCC4 expression and immune infiltrating cell level correlation result in HPV+ samples
ERCC4 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).