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HBV Target gene Detail Information

> ERBB4 Gene Search Result


Gene Information
Gene Name ERBB4
Gene ID 2066
Gene Full Name erb-b2 receptor tyrosine kinase 4
Gene Alias HER4; ALS19; p180erbB4
Transcripts ENSG00000178568
Virus HBV
Gene Type protein coding
HPA Location Info
Membrane Info Predicted membrane proteins
HPA Protein Class Info Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Gene Function Suppressor gene & Oncogene
Uniport_ID Q15303
HGNC ID HGNC:3432
VEGA ID OTTHUMG00000133012
OMIM ID 600543
String ID 9606.ENSP00000342235
Drugbank ID BE0004772
Drug (Cytoscape Annotation) Lapatinib Ditosylate;Gefitinib;Dasatinib;AfatinibDimaleate;Bosutinib;Erlotinib Hydrochloride;Vandetanib
PharmGKB ID PA27847
FDA Approved Drug Dacomitinib
Target gene [ERBB4] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1007057 chr2 13 17 1 31 View
1007911 chr2 8 13 2 23 View
1009822 chr2 14 14 View
1010166 chr2 13 13 View
1010458 chr2 7 1 4 12 View
1010706 chr2 3 8 11 View
1014226 chr2 3 1 4 View
1014340 chr2 3 3 View
1016817 chr2 1 1 View
1401982 chr2 8 13 2 23 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of ERBB4 expression and immune infiltrating cell level correlation result in HBV+ samples
ERBB4 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).