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HPV Target gene Detail Information

> ERBB2 Gene Search Result


Gene Information
Gene Name ERBB2
Gene ID 2064
Gene Full Name erb-b2 receptor tyrosine kinase 2
Gene Alias NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu
Transcripts ENSG00000141736
Virus HPV
Gene Type protein coding
HPA Location Info Plasma membrane;Cytosol;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Gene Function Oncogene
Uniport_ID P04626
HGNC ID HGNC:3430
VEGA ID OTTHUMG00000179300
OMIM ID 164870
String ID 9606.ENSP00000269571
Drugbank ID BE0000511
PharmGKB ID PA27844
FDA Approved Drug Abemaciclib;Ado-Trastuzumab Emtansine;Alpelisib;Eribulin;Everolimus;Fam-Trastuzumab Deruxtecan-nxki;Fulvestrant;Ixabepilone;Lapatinib;Margetuximab-cmkb;Neratinib;Olaparib;Palbociclib;Pertuzumab;Ribociclib;Talazoparib;Tipiracil;Trifluridine;Trastuzumab;Tucatinib
Target gene [ERBB2] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
5000185 chr17 131 426 185 742 View
5000546 chr17 114 25 1 140 View
5000589 chr17 115 11 126 View
5000590 chr17 115 11 126 View
5000591 chr17 114 12 126 View
5000773 chr17 80 7 87 View
5002783 chr17 7 1 8 View
5300273 chr17 238 214 55 507 View
5300274 chr17 243 168 49 460 View
5300275 chr17 85 4 89 View
5300276 chr17 666 4 3 673 View
5300277 chr17 767 14 21 802 View
5300278 chr17 41 10 19 70 View
5300279 chr17 79 3 82 View
5300280 chr17 4 4 View
5300281 chr17 4 1 5 View
5402648 chr17 1 2 3 View
5402649 chr17 31 6 37 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE140662 (GEO) Condyloma Acuminatum 8 Condyloma acuminata (HPV+)(5), Skin(3)
GSE65858 (GEO) Head and neck squamous cell carcinoma 270 Head and neck squamous cell carcinoma (EBV+)(73), Head and neck squamous cell carcinoma (EBV-)(197)
GSE40774 (GEO) Head and neck squamous cell carcinoma 134 Head and neck Squamous cell carcinomas GLOTTIC LARYNX (EBV-)(2), Head and neck Squamous cell carcinomas HYPOPHARYNX (EBV-)(9), Head and neck Squamous cell carcinomas ORAL CAVITY (EBV-)(23), Head and neck Squamous cell carcinomas ORAL CAVITY (EBV+)(2), Head and neck Squamous cell carcinomas OROPHARYNX (EBV-)(22), Head and neck Squamous cell carcinomas OROPHARYNX (EBV+)(54), Head and neck Squamous cell carcinomas OTHER (EBV+)(1), Head and neck Squamous cell carcinomas SUBGLOTTIC LARYNX (EBV-)(1), Head and neck Squamous cell carcinomas SUPRAGLOTTIC (EBV-)(19), Squamous cell carcinomas SUPRAGLOTTIC (EBV+)(1)
GSE55546 (GEO) Oropharyngeal squamous cell carcinoma 16 Oropharyngeal cancers (HPV+)(12), Normal (4)
GSE55544 (GEO) Oropharyngeal squamous cell carcinoma 23 Oropharyngeal cancers HPV Active (11), Oropharyngeal cancers HPV Inactive (4), Oropharyngeal cancers HPV Negative (8)
GSE55542 (GEO) Oropharyngeal squamous cell carcinoma 36 Oropharyngeal cancers HPV Active (12), Oropharyngeal cancers HPV Inactive (8), Oropharyngeal cancers HPV Negative (16)
GSE138080 (GEO) Cervical intraepithelial neoplasia 25 Normal (10), Cervical intraepithelial neoplasia (HPV+)(15)
GSE51993 (GEO) Cervical intraepithelial neoplasia 24 Cervical intraepithelial neoplasia (HPV+)(17), Normal(7)
HNSC (TCGA) Head and Neck squamous cell carcinoma 566 Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE140662

HeatMap of cell type fractions in all samples Lollipop of ERBB2 expression and immune infiltrating cell level correlation result in HPV+ samples
ERBB2 expression: Low -> High

> Dataset: GSE65858

HeatMap of cell type fractions in all samples Lollipop of ERBB2 expression and immune infiltrating cell level correlation result in HPV+ samples
ERBB2 expression: Low -> High

> Dataset: GSE40774

HeatMap of cell type fractions in all samples Lollipop of ERBB2 expression and immune infiltrating cell level correlation result in HPV+ samples
ERBB2 expression: Low -> High

> Dataset: GSE55546

HeatMap of cell type fractions in all samples Lollipop of ERBB2 expression and immune infiltrating cell level correlation result in HPV+ samples
ERBB2 expression: Low -> High

> Dataset: GSE55544

HeatMap of cell type fractions in all samples Lollipop of ERBB2 expression and immune infiltrating cell level correlation result in HPV+ samples
ERBB2 expression: Low -> High

> Dataset: GSE55542

HeatMap of cell type fractions in all samples Lollipop of ERBB2 expression and immune infiltrating cell level correlation result in HPV+ samples
ERBB2 expression: Low -> High

> Dataset: GSE138080

HeatMap of cell type fractions in all samples Lollipop of ERBB2 expression and immune infiltrating cell level correlation result in HPV+ samples
ERBB2 expression: Low -> High

> Dataset: GSE51993

HeatMap of cell type fractions in all samples Lollipop of ERBB2 expression and immune infiltrating cell level correlation result in HPV+ samples
ERBB2 expression: Low -> High

> Dataset: HNSC

HeatMap of cell type fractions in all samples Lollipop of ERBB2 expression and immune infiltrating cell level correlation result in HPV+ samples
ERBB2 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).