HIV Target gene Detail Information

> ERAP1 Gene Search Result

Gene Information

Gene Name	ERAP1
Gene ID	51752
Gene Full Name	endoplasmic reticulum aminopeptidase 1
Gene Alias	ALAP; A-LAP; ARTS1; ERAAP; APPILS; ARTS-1; ERAAP1; PILSAP; PILS-AP
Transcripts	ENSG00000164307
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;Nucleoplasm;Plasma membrane;Predicted to be secreted;
HPA Protein Class Info	Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Uniport_ID	Q9NZ08
HGNC ID	HGNC:18173
VEGA ID	OTTHUMG00000128721
OMIM ID	606832
String ID	9606.ENSP00000296754
PharmGKB ID	PA162385163

Target gene [ERAP1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4004189	chr5	47	1		48	View
4011004	chr5	6	1		7	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of ERAP1 expression and immune infiltrating cell level correlation result in HIV+ samples
ERAP1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of ERAP1 expression and immune infiltrating cell level correlation result in HIV+ samples
ERAP1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).