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HTLV1 Target gene Detail Information

> EPHB2 Gene Search Result


Gene Information
Gene Name EPHB2
Gene ID 2048
Gene Full Name EPH receptor B2
Gene Alias DRT; EK5; ERK; CAPB; Hek5; PCBC; EPHT3; Tyro5
Transcripts ENSG00000133216
Virus HTLV1
Gene Type protein coding
HPA Location Info Plasma membrane;Nucleoplasm;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins
Gene Function Suppressor gene
Uniport_ID P29323
HGNC ID HGNC:3393
VEGA ID OTTHUMG00000002881
OMIM ID 600997
String ID 9606.ENSP00000363763
Drugbank ID BE0004549
PharmGKB ID PA27825
Target gene [EPHB2] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6001684 chr1 239 19 109 367 View
6013425 chr1 10 7 2 19 View
6014502 chr1 7 7 2 16 View
6024559 chr1 3 3 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of EPHB2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
EPHB2 expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of EPHB2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
EPHB2 expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of EPHB2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
EPHB2 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).