HBV Target gene Detail Information

> EPHA6 Gene Search Result

Gene Information

Gene Name	EPHA6
Gene ID	285220
Gene Full Name	EPH receptor A6
Gene Alias	EHK2; EK12; EPA6; EHK-2; HEK12; PRO57066
Transcripts	ENSG00000080224
Virus	HBV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Enzymes, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	Q9UF33
HGNC ID	HGNC:19296
VEGA ID	OTTHUMG00000159208
OMIM ID	600066
String ID	9606.ENSP00000374323
Drugbank ID	BE0009393
Drug (Cytoscape Annotation)	Vandetanib;Sorafenib Tosylate;Erlotinib Hydrochloride;Nilotinib;Gefitinib;AfatinibDimaleate;Crizotinib;Sunitinib Malate
PharmGKB ID	PA134866684

Target gene [EPHA6] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1010535	chr3	11	1		12	View
1018237	chr3				0	View
1018238	chr3				0	View
1400534	chr3	206	38	35	279	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of EPHA6 expression and immune infiltrating cell level correlation result in HBV+ samples
EPHA6 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).