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HBV Target gene Detail Information

> EPHA3 Gene Search Result


Gene Information
Gene Name EPHA3
Gene ID 2042
Gene Full Name EPH receptor A3
Gene Alias EK4; ETK; HEK; ETK1; HEK4; TYRO4
Transcripts ENSG00000044524
Virus HBV
Gene Type protein coding
HPA Location Info Cytosol;Nuclear membrane;Plasma membrane;Actin filaments;Nucleoplasm;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins
Gene Function Suppressor gene
Uniport_ID P29320
HGNC ID HGNC:3387
VEGA ID OTTHUMG00000159040
OMIM ID 179611
String ID 9606.ENSP00000337451
Drugbank ID BE0009391
Drug (Cytoscape Annotation) Bosutinib;Nilotinib;Crizotinib;Dasatinib
PharmGKB ID PA27819
Target gene [EPHA3] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1019454 chr3 0 View
1400379 chr3 1 48 49 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of EPHA3 expression and immune infiltrating cell level correlation result in HBV+ samples
EPHA3 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).