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HTLV1 Target gene Detail Information

> EPHA2 Gene Search Result


Gene Information
Gene Name EPHA2
Gene ID 1969
Gene Full Name EPH receptor A2
Gene Alias ECK; CTPA; ARCC2; CTPP1; CTRCT6
Transcripts ENSG00000142627
Virus HTLV1
Gene Type protein coding
HPA Location Info Cell Junctions;Plasma membrane;Golgi apparatus;Nuclear speckles;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Predicted membrane proteins, RAS pathway related proteins
Gene Function Suppressor gene & Oncogene
Uniport_ID P29317
HGNC ID HGNC:3386
VEGA ID OTTHUMG00000009527
OMIM ID 176946
String ID 9606.ENSP00000351209
Drugbank ID BE0000841
PharmGKB ID PA27818
Target gene [EPHA2] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6004245 chr1 110 13 123 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of EPHA2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
EPHA2 expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of EPHA2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
EPHA2 expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of EPHA2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
EPHA2 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).