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HBV Target gene Detail Information

> EPAS1 Gene Search Result


Gene Information
Gene Name EPAS1
Gene ID 2034
Gene Full Name endothelial PAS domain protein 1
Gene Alias HLF; MOP2; ECYT4; HIF2A; PASD2; bHLHe73
Transcripts ENSG00000116016
Virus HBV
Gene Type protein coding
HPA Location Info Nucleoplasm;Cytosol;
HPA Protein Class Info Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors
Gene Function Suppressor gene
Uniport_ID Q99814
HGNC ID HGNC:3374
VEGA ID OTTHUMG00000128818
OMIM ID 603349
String ID 9606.ENSP00000263734
Drugbank ID BE0009589; BE0009679
PharmGKB ID PA27809
Target gene [EPAS1] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1008023 chr2 17 6 23 View
1010840 chr2 9 1 1 11 View
1011966 chr2 8 8 View
1015069 chr2 1 2 3 View
1015075 chr2 1 2 3 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of EPAS1 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
EPAS1 expression: Low -> High
Lollipop of EPAS1 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of EPAS1 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of EPAS1 expression and immune infiltrating cell level correlation result in HBV+ samples
EPAS1 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).