HIV Target gene Detail Information

> EP300 Gene Search Result

Gene Information

Gene Name	EP300
Gene ID	2033
Gene Full Name	E1A binding protein p300
Gene Alias	p300; KAT3B; RSTS2
Transcripts	ENSG00000100393
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;
HPA Protein Class Info	Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Uniport_ID	Q09472
HGNC ID	HGNC:3373
VEGA ID	OTTHUMG00000150937
OMIM ID	602700
String ID	9606.ENSP00000263253
PharmGKB ID	PA27807

Target gene [EP300] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4001798	chr22	78	27	26	131	View
4002273	chr22	101	1		102	View
4003594	chr22	34	4	20	58	View
4004662	chr22	38	3		41	View
4004920	chr22	32	4	2	38	View
4005281	chr22	9	25		34	View
4006416	chr22	24	1		25	View
4007859	chr22	1	11	5	17	View
4008853	chr22	12	1		13	View
4010426	chr22	6	3		9	View
4013201	chr22	1	3		4	View
4013907	chr22	1	2		3	View
4300050	chr22	14			14	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of EP300 expression and immune infiltrating cell level correlation result in HIV+ samples
EP300 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of EP300 expression and immune infiltrating cell level correlation result in HIV+ samples
EP300 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).