HIV Target gene Detail Information

> ENG Gene Search Result

Gene Information

Gene Name	ENG
Gene ID	2022
Gene Full Name	endoglin
Gene Alias	END; HHT1; ORW1
Transcripts	ENSG00000106991
Virus	HIV
Gene Type	protein coding
HPA Location Info	Plasma membrane;Nuclear bodies;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Cancer-related genes, Candidate cardiovascular disease genes, CD markers, Disease related genes, Plasma proteins, Predicted membrane proteins
Uniport_ID	P17813
HGNC ID	HGNC:3349
VEGA ID	OTTHUMG00000020723
OMIM ID	131195
String ID	9606.ENSP00000362299
Drugbank ID	BE0003494
PharmGKB ID	PA27785

Target gene [ENG] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4001595	chr9	7	139	2	148	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of ENG expression and immune infiltrating cell level correlation result in HIV+ samples
ENG expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of ENG expression and immune infiltrating cell level correlation result in HIV+ samples
ENG expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).