HIV Target gene Detail Information

> EIF5B Gene Search Result

Gene Information

Gene Name	EIF5B
Gene ID	9669
Gene Full Name	eukaryotic translation initiation factor 5B
Gene Alias	IF2
Transcripts	ENSG00000158417
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;Plasma membrane;
HPA Protein Class Info	Enzymes, Plasma proteins, Predicted intracellular proteins
Uniport_ID	O60841
HGNC ID	HGNC:30793
VEGA ID	OTTHUMG00000153242
OMIM ID	606086
String ID	9606.ENSP00000289371
PharmGKB ID	PA134864457

Target gene [EIF5B] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4009948	chr2	3	4	3	10	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of EIF5B expression and immune infiltrating cell level correlation result in HIV+ samples
EIF5B expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of EIF5B expression and immune infiltrating cell level correlation result in HIV+ samples
EIF5B expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).