HTLV1 Target gene Detail Information

> EIF4E3 Gene Search Result

Gene Information

Gene Name	EIF4E3
Gene ID	317649
Gene Full Name	eukaryotic translation initiation factor 4E family member 3
Gene Alias	eIF-4E3; eIF4E-3
Transcripts	ENSG00000163412
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Nucleoli fibrillar center;
HPA Protein Class Info	Predicted intracellular proteins
Uniport_ID	Q8N5X7
HGNC ID	HGNC:31837
VEGA ID	OTTHUMG00000158797
OMIM ID	609896
String ID	9606.ENSP00000393324
PharmGKB ID	PA134961880

Target gene [EIF4E3] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6000477	chr3	1245	171	48	1464	View
6001198	chr3	463	64	11	538	View
6009709	chr3	24	11		35	View
6023509	chr3	4			4	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of EIF4E3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
EIF4E3 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of EIF4E3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
EIF4E3 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of EIF4E3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
EIF4E3 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).