HTLV1 Target gene Detail Information

> EIF4A2 Gene Search Result

Gene Information

Gene Name	EIF4A2
Gene ID	1974
Gene Full Name	eukaryotic translation initiation factor 4A2
Gene Alias	DDX2B; EIF4A; EIF4F; BM-010; eIF4A-II; eIF-4A-II
Transcripts	ENSG00000156976
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Cytosol;
HPA Protein Class Info	Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins
Uniport_ID	Q14240
HGNC ID	HGNC:3284
VEGA ID	OTTHUMG00000156564
OMIM ID	601102
String ID	9606.ENSP00000326381
PharmGKB ID	PA27712

Target gene [EIF4A2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6003541	chr3	64	88	2	154	View
6006893	chr3	62			62	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of EIF4A2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
EIF4A2 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of EIF4A2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
EIF4A2 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of EIF4A2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
EIF4A2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).