HIV Target gene Detail Information

> EIF2B3 Gene Search Result

Gene Information

Gene Name	EIF2B3
Gene ID	8891
Gene Full Name	eukaryotic translation initiation factor 2B subunit gamma
Gene Alias	EIF-2B; EIF2Bgamma
Transcripts	ENSG00000070785
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;Vesicles;
HPA Protein Class Info	Disease related genes, Predicted intracellular proteins
Uniport_ID	Q9NR50
HGNC ID	HGNC:3259
VEGA ID	OTTHUMG00000008585
OMIM ID	606273
String ID	9606.ENSP00000353575
PharmGKB ID	PA27690

Target gene [EIF2B3] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4003987	chr1	35	7	9	51	View
4005808	chr1	28	1		29	View
4005870	chr1	26	3		29	View
4007231	chr1	1	9	10	20	View
4008588	chr1	13		1	14	View
4009506	chr1	7	4		11	View
4009795	chr1	7		3	10	View
4010649	chr1	7	1		8	View
4014260	chr1	2			2	View
4015199	chr1	1			1	View
4016114	chr1				0	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of EIF2B3 expression and immune infiltrating cell level correlation result in HIV+ samples
EIF2B3 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of EIF2B3 expression and immune infiltrating cell level correlation result in HIV+ samples
EIF2B3 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).