HTLV1 Target gene Detail Information

> EIF2AK3 Gene Search Result

Gene Information

Gene Name	EIF2AK3
Gene ID	9451
Gene Full Name	eukaryotic translation initiation factor 2 alpha kinase 3
Gene Alias	PEK; WRS; PERK
Transcripts	ENSG00000172071
Virus	HTLV1
Gene Type	protein coding
HPA Location Info
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Disease related genes, Enzymes, Potential drug targets, Predicted membrane proteins
Uniport_ID	Q9NZJ5
HGNC ID	HGNC:3255
VEGA ID	OTTHUMG00000155046
OMIM ID	604032
String ID	9606.ENSP00000307235
PharmGKB ID	PA27687

Target gene [EIF2AK3] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6000389	chr2	1714	70	10	1794	View
6032178	chr2				0	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of EIF2AK3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
EIF2AK3 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of EIF2AK3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
EIF2AK3 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of EIF2AK3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
EIF2AK3 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).