HIV Target gene Detail Information

> EIF2AK2 Gene Search Result

Gene Information

Gene Name	EIF2AK2
Gene ID	5610
Gene Full Name	eukaryotic translation initiation factor 2 alpha kinase 2
Gene Alias	PKR; PRKR; EIF2AK1; PPP1R83
Transcripts	ENSG00000055332
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;
HPA Protein Class Info	Enzymes, Predicted intracellular proteins
Uniport_ID	P19525
HGNC ID	HGNC:9437
VEGA ID	OTTHUMG00000100962
OMIM ID	176871
String ID	9606.ENSP00000233057
Drugbank ID	BE0009388
PharmGKB ID	PA33779

Target gene [EIF2AK2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4003891	chr2	50	3		53	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of EIF2AK2 expression and immune infiltrating cell level correlation result in HIV+ samples
EIF2AK2 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of EIF2AK2 expression and immune infiltrating cell level correlation result in HIV+ samples
EIF2AK2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).