HTLV1 Target gene Detail Information

> EGLN3 Gene Search Result

Gene Information

Gene Name	EGLN3
Gene ID	112399
Gene Full Name	egl-9 family hypoxia inducible factor 3
Gene Alias	PHD3; HIFPH3; HIFP4H3
Transcripts	ENSG00000129521
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Cytosol;
HPA Protein Class Info	Enzymes, Predicted intracellular proteins
Gene Function	Suppressor gene
Uniport_ID	Q9H6Z9
HGNC ID	HGNC:14661
VEGA ID	OTTHUMG00000029498
OMIM ID	606426
String ID	9606.ENSP00000250457
Drugbank ID	BE0002219
PharmGKB ID	PA27672

Target gene [EGLN3] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6006294	chr14	15	30	26	71	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of EGLN3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
EGLN3 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of EGLN3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
EGLN3 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of EGLN3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
EGLN3 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).