HPV Target gene Detail Information

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Gene Information

Gene Name	EGFR
Gene ID	1956
Gene Full Name	epidermal growth factor receptor
Gene Alias	ERBB; HER1; mENA; ERBB1; PIG61; NISBD2
Transcripts	ENSG00000146648
Virus	HPV
Gene Type	protein coding
HPA Location Info	Cell Junctions;Plasma membrane;Predicted to be secreted;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins
Gene Function	Oncogene
Uniport_ID	P00533
HGNC ID	HGNC:3236
VEGA ID	OTTHUMG00000023661
OMIM ID	131550
String ID	9606.ENSP00000275493
Drugbank ID	BE0000767
Drug (Cytoscape Annotation)	Gefitinib;Erlotinib Hydrochloride;Dasatinib;AfatinibDimaleate;Lapatinib Ditosylate;Vandetanib;Docetaxel;Panitumumab;Cetuximab;Imatinib Mesylate;Ibrutinib;Sunitinib Malate;Bosutinib;Necitumumab
PharmGKB ID	PA7360
FDA Approved Drug	Afatinib;Panitumumab;Erlotinib;Gefitinib;Dacomitinib;Cetuximab;Necitumumab;Osimertinib;Vandetanib;Lapatinib;Atezolizumab;Ipilimumab;Nivolumab;Pembrolizumab;Ramucirumab

Target gene [EGFR] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
5001796	chr7	19		3	22	View
5201404	chr7	5			5	View
5402769	chr7	1	4		5	View

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).