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HBV Target gene Detail Information

> E4F1 Gene Search Result


Gene Information
Gene Name E4F1
Gene ID 1877
Gene Full Name E4F transcription factor 1
Gene Alias E4F
Transcripts ENSG00000167967
Virus HBV
Gene Type protein coding
HPA Location Info Nucleoplasm;
HPA Protein Class Info Enzymes, Predicted intracellular proteins, Transcription factors
Uniport_ID Q66K89
HGNC ID HGNC:3121
VEGA ID OTTHUMG00000177084
OMIM ID 603022
String ID 9606.ENSP00000301727
PharmGKB ID PA27579
Target gene [E4F1] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1004912 chr16 62 4 66 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of E4F1 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
E4F1 expression: Low -> High
Lollipop of E4F1 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of E4F1 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of E4F1 expression and immune infiltrating cell level correlation result in HBV+ samples
E4F1 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).