HIV Target gene Detail Information

> E2F3 Gene Search Result

Gene Information

Gene Name	E2F3
Gene ID	1871
Gene Full Name	E2F transcription factor 3
Gene Alias	E2F-3
Transcripts	ENSG00000112242
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nuclear speckles;Nucleoplasm;Cytosol;
HPA Protein Class Info	Cancer-related genes, Predicted intracellular proteins, Transcription factors
Gene Function	Suppressor gene & Oncogene
Uniport_ID	O00716
HGNC ID	HGNC:3115
VEGA ID	OTTHUMG00000016389
OMIM ID	600427
String ID	9606.ENSP00000262904
PharmGKB ID	PA27573

Target gene [E2F3] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4004146	chr6	39	6	3	48	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of E2F3 expression and immune infiltrating cell level correlation result in HIV+ samples
E2F3 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of E2F3 expression and immune infiltrating cell level correlation result in HIV+ samples
E2F3 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).