HIV Target gene Detail Information

> DYRK1A Gene Search Result

Gene Information

Gene Name	DYRK1A
Gene ID	1859
Gene Full Name	dual specificity tyrosine phosphorylation regulated kinase 1A
Gene Alias	MNB; DYRK; HP86; MNBH; MRD7; DYRK1
Transcripts	ENSG00000157540
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;Nucleoli fibrillar center;
HPA Protein Class Info	Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Uniport_ID	Q13627
HGNC ID	HGNC:3091
VEGA ID	OTTHUMG00000086657
OMIM ID	600855
String ID	9606.ENSP00000381932
Drugbank ID	BE0004012
PharmGKB ID	PA27545

Target gene [DYRK1A] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4002000	chr21	18	99	1	118	View
4002890	chr21	47	15	14	76	View
4010159	chr21	8	1		9	View
4012299	chr21	2	1	2	5	View
4013905	chr21	1	2		3	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of DYRK1A expression and immune infiltrating cell level correlation result in HIV+ samples
DYRK1A expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of DYRK1A expression and immune infiltrating cell level correlation result in HIV+ samples
DYRK1A expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).