HBV Target gene Detail Information

> DTX1 Gene Search Result

Gene Information

Gene Name	DTX1
Gene ID	1840
Gene Full Name	deltex E3 ubiquitin ligase 1
Gene Alias	hDx-1; RNF140
Transcripts	ENSG00000135144
Virus	HBV
Gene Type	protein coding
HPA Location Info	Cytosol;Nucleoplasm;Nuclear bodies;
HPA Protein Class Info	Enzymes, Predicted intracellular proteins
Uniport_ID	Q86Y01
HGNC ID	HGNC:3060
VEGA ID	OTTHUMG00000169610
OMIM ID	602582
String ID	9606.ENSP00000257600
PharmGKB ID	PA27514

Target gene [DTX1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1002490	chr12	32	186	48	266	View
1002670	chr12	28	157	40	225	View
1002975	chr12	69	95	17	181	View
1003601	chr12	52	62	7	121	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE114783 (GEO)	Chronic HBV (CHB) infection	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Hepatocellular carcinoma	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Liver cirrhosis	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783
HeatMap of cell type fractions in all samples	Lollipop of DTX1 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
DTX1 expression: Low -> High
Lollipop of DTX1 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples	Lollipop of DTX1 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples


> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of DTX1 expression and immune infiltrating cell level correlation result in HBV+ samples
DTX1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).