HIV Target gene Detail Information

> DOCK8 Gene Search Result

Gene Information

Gene Name	DOCK8
Gene ID	81704
Gene Full Name	dedicator of cytokinesis 8
Gene Alias	MRD2; ZIR8; HEL-205
Transcripts	ENSG00000107099
Virus	HIV
Gene Type	protein coding
HPA Location Info	Centrosome;Cytosol;Mitochondria;Nucleoplasm;
HPA Protein Class Info	Disease related genes, Predicted intracellular proteins
Uniport_ID	Q8NF50
HGNC ID	HGNC:19191
VEGA ID	OTTHUMG00000078789
OMIM ID	611432
String ID	9606.ENSP00000394888
PharmGKB ID	PA134918866

Target gene [DOCK8] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000601	chr9	78	107	166	351	View
4001319	chr9	162	4	13	179	View
4003152	chr9	8	60		68	View
4013748	chr9	3			3	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of DOCK8 expression and immune infiltrating cell level correlation result in HIV+ samples
DOCK8 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of DOCK8 expression and immune infiltrating cell level correlation result in HIV+ samples
DOCK8 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).