HTLV1 Target gene Detail Information

> DOCK1 Gene Search Result

Gene Information

Gene Name	DOCK1
Gene ID	1793
Gene Full Name	dedicator of cytokinesis 1
Gene Alias	ced5; DOCK180
Transcripts	ENSG00000150760
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Nucleoplasm;
HPA Protein Class Info	Plasma proteins, Predicted intracellular proteins
Uniport_ID	Q14185
HGNC ID	HGNC:2987
VEGA ID	OTTHUMG00000019249
OMIM ID	601403
String ID	9606.ENSP00000280333
PharmGKB ID	PA27453

Target gene [DOCK1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6007388	chr10	3	47	6	56	View
6017181	chr10	11			11	View
6019450	chr10	7	1		8	View
6021377	chr10	4	2		6	View
6026155	chr10	1	1		2	View
6031054	chr10				0	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of DOCK1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
DOCK1 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of DOCK1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
DOCK1 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of DOCK1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
DOCK1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).