HIV Target gene Detail Information

> DNMT3B Gene Search Result

Gene Information

Gene Name	DNMT3B
Gene ID	1789
Gene Full Name	DNA methyltransferase 3 beta
Gene Alias	ICF; ICF1; M.HsaIIIB
Transcripts	ENSG00000088305
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;
HPA Protein Class Info	Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Transcription factors
Gene Function	Suppressor gene
Uniport_ID	Q9UBC3
HGNC ID	HGNC:2979
VEGA ID	OTTHUMG00000032226
OMIM ID	602900
String ID	9606.ENSP00000328547
Drugbank ID	BE0010437; BE0010009
PharmGKB ID	PA27446

Target gene [DNMT3B] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4001047	chr20	72	33	120	225	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of DNMT3B expression and immune infiltrating cell level correlation result in HIV+ samples
DNMT3B expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).