HIV Target gene Detail Information

> DNMT3A Gene Search Result

Gene Information

Gene Name	DNMT3A
Gene ID	1788
Gene Full Name	DNA methyltransferase 3 alpha
Gene Alias	TBRS; DNMT3A2; M.HsaIIIA
Transcripts	ENSG00000119772
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;
HPA Protein Class Info	Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transcription factors
Gene Function	Suppressor gene
Uniport_ID	Q9Y6K1
HGNC ID	HGNC:2978
VEGA ID	OTTHUMG00000094777
OMIM ID	602769
String ID	9606.ENSP00000264709
Drugbank ID	BE0010170; BE0009880
PharmGKB ID	PA27445

Target gene [DNMT3A] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4012279	chr2	5			5	View
4300086	chr2	8	6	1	15	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of DNMT3A expression and immune infiltrating cell level correlation result in HIV+ samples
DNMT3A expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of DNMT3A expression and immune infiltrating cell level correlation result in HIV+ samples
DNMT3A expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).