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HBV Target gene Detail Information

> DNMT1 Gene Search Result


Gene Information
Gene Name DNMT1
Gene ID 1786
Gene Full Name DNA methyltransferase 1
Gene Alias AIM; DNMT; MCMT; CXXC9; HSN1E; ADCADN; m.HsaI
Transcripts ENSG00000130816
Virus HBV
Gene Type protein coding
HPA Location Info Nucleoplasm;
HPA Protein Class Info Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Transcription factors
Gene Function Suppressor gene
Uniport_ID P26358
HGNC ID HGNC:2976
VEGA ID OTTHUMG00000180397
OMIM ID 126375
String ID 9606.ENSP00000352516
Drugbank ID BE0000892
PharmGKB ID PA27443
Target gene [DNMT1] related to virus gene/protein/region
ID PMID Mutation Gene/Protein/Region Description Detail
1 27132039 G1764A
BCP
G
 View

Target gene [DNMT1] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1007366 chr19 15 13 28 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of DNMT1 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
DNMT1 expression: Low -> High
Lollipop of DNMT1 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of DNMT1 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of DNMT1 expression and immune infiltrating cell level correlation result in HBV+ samples
DNMT1 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).