HIV Target gene Detail Information

> DNASE1 Gene Search Result

Gene Information

Gene Name	DNASE1
Gene ID	1773
Gene Full Name	deoxyribonuclease 1
Gene Alias	DNL1; DRNI
Transcripts	ENSG00000213918
Virus	HIV
Gene Type	protein coding
HPA Location Info	Vesicles;Predicted to be secreted;
HPA Protein Class Info	Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins
Uniport_ID	P24855
HGNC ID	HGNC:2956
VEGA ID	OTTHUMG00000129426
OMIM ID	125505
String ID	9606.ENSP00000385905
PharmGKB ID	PA27427

Target gene [DNASE1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000127	chr16	307	351	327	985	View
4000138	chr16	304	313	317	934	View
4000186	chr16	276	256	268	800	View
4000232	chr16	274	204	200	678	View
4000386	chr16	270	118	108	496	View
4000864	chr16	162	28	72	262	View
4003404	chr16	54	8		62	View
4012066	chr16	4	1		5	View
4012067	chr16	2	3		5	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of DNASE1 expression and immune infiltrating cell level correlation result in HIV+ samples
DNASE1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).