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HTLV1 Target gene Detail Information

> DKK1 Gene Search Result


Gene Information
Gene Name DKK1
Gene ID 22943
Gene Full Name dickkopf WNT signaling pathway inhibitor 1
Gene Alias SK; DKK-1
Transcripts ENSG00000107984
Virus HTLV1
Gene Type protein coding
HPA Location Info
HPA Protein Class Info Predicted secreted proteins
Gene Function Suppressor gene
Uniport_ID O94907
HGNC ID HGNC:2891
VEGA ID OTTHUMG00000018247
OMIM ID 605189
String ID 9606.ENSP00000363081
PharmGKB ID PA27345
Target gene [DKK1] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6000373 chr10 1356 402 159 1917 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of DKK1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
DKK1 expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of DKK1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
DKK1 expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of DKK1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
DKK1 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).