HIV Target gene Detail Information

> DKC1 Gene Search Result

Gene Information

Gene Name	DKC1
Gene ID	1736
Gene Full Name	dyskerin pseudouridine synthase 1
Gene Alias	DKC; CBF5; DKCX; NAP57; NOLA4; XAP101
Transcripts	ENSG00000130826
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoli fibrillar center;Nucleoplasm;
HPA Protein Class Info	Disease related genes, Plasma proteins, Predicted intracellular proteins
Uniport_ID	O60832
HGNC ID	HGNC:2890
VEGA ID	OTTHUMG00000024242
OMIM ID	300126
String ID	9606.ENSP00000358563
PharmGKB ID	PA27344

Target gene [DKC1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4011301	chrX	4	2	1	7	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of DKC1 expression and immune infiltrating cell level correlation result in HIV+ samples
DKC1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).