HIV Target gene Detail Information

> DICER1 Gene Search Result

Gene Information

Gene Name	DICER1
Gene ID	23405
Gene Full Name	dicer 1, ribonuclease III
Gene Alias	DCR1; MNG1; Dicer; HERNA; RMSE2; Dicer1e; K12H4.8-LIKE
Transcripts	ENSG00000100697
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;
HPA Protein Class Info	Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Gene Function	Suppressor gene
Uniport_ID	Q9UPY3
HGNC ID	HGNC:17098
VEGA ID	OTTHUMG00000166134
OMIM ID	606241
String ID	9606.ENSP00000437256
PharmGKB ID	PA38437

Target gene [DICER1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4003712	chr14	12	36	8	56	View
4004301	chr14	9	36	1	46	View
4008764	chr14	11	3		14	View
4009136	chr14	4	8		12	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of DICER1 expression and immune infiltrating cell level correlation result in HIV+ samples
DICER1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of DICER1 expression and immune infiltrating cell level correlation result in HIV+ samples
DICER1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).