HIV Target gene Detail Information

> DIAPH1 Gene Search Result

Gene Information

Gene Name	DIAPH1
Gene ID	1729
Gene Full Name	diaphanous related formin 1
Gene Alias	DIA1; DRF1; DFNA1; LFHL1; SCBMS; hDIA1
Transcripts	ENSG00000131504
Virus	HIV
Gene Type	protein coding
HPA Location Info	Plasma membrane;
HPA Protein Class Info	Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins
Uniport_ID	O60610
HGNC ID	HGNC:2876
VEGA ID	OTTHUMG00000149893
OMIM ID	602121
String ID	9606.ENSP00000381565
PharmGKB ID	PA27333

Target gene [DIAPH1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4001356	chr5	172	2		174	View
4001536	chr5	153			153	View
4002498	chr5	58	31	3	92	View
4009588	chr5	3	8		11	View
4012332	chr5	5			5	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of DIAPH1 expression and immune infiltrating cell level correlation result in HIV+ samples
DIAPH1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of DIAPH1 expression and immune infiltrating cell level correlation result in HIV+ samples
DIAPH1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).