HIV Target gene Detail Information

> DHX8 Gene Search Result


Gene Information
Gene Name DHX8
Gene ID 1659
Gene Full Name DEAH-box helicase 8
Gene Alias DDX8; Dhr2; HRH1; PRP22; PRPF22
Transcripts ENSG00000067596
Virus HIV
Gene Type protein coding
HPA Location Info Nucleoplasm;Nuclear bodies;
HPA Protein Class Info Enzymes, Plasma proteins, Predicted intracellular proteins
Uniport_ID Q14562
HGNC ID HGNC:2749
VEGA ID OTTHUMG00000180883
OMIM ID 600396
String ID 9606.ENSP00000262415
PharmGKB ID PA27231
Target gene [DHX8] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
4001818 chr17 120 9 129 View
4009381 chr17 10 2 12 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE17372 (GEO) AIDS-associated lymphoma 17 AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO) HIV-infected disease 44 HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372

HeatMap of cell type fractions in all samples Lollipop of DHX8 expression and immune infiltrating cell level correlation result in HIV+ samples
DHX8 expression: Low -> High

> Dataset: GSE50834

HeatMap of cell type fractions in all samples Lollipop of DHX8 expression and immune infiltrating cell level correlation result in HIV+ samples
DHX8 expression: Low -> High

Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).