HIV Target gene Detail Information

> DHTKD1 Gene Search Result

Gene Information

Gene Name	DHTKD1
Gene ID	55526
Gene Full Name	dehydrogenase E1 and transketolase domain containing 1
Gene Alias	CMT2Q; AMOXAD
Transcripts	ENSG00000181192
Virus	HIV
Gene Type	protein coding
HPA Location Info	Mitochondria;
HPA Protein Class Info	Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Uniport_ID	Q96HY7
HGNC ID	HGNC:23537
VEGA ID	OTTHUMG00000017677
OMIM ID	614984
String ID	9606.ENSP00000263035
PharmGKB ID	PA134962952

Target gene [DHTKD1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000508	chr10	365	41	4	410	View
4000593	chr10	350	2	3	355	View
4014590	chr10	2			2	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of DHTKD1 expression and immune infiltrating cell level correlation result in HIV+ samples
DHTKD1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of DHTKD1 expression and immune infiltrating cell level correlation result in HIV+ samples
DHTKD1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).