HIV Target gene Detail Information

> DHFR Gene Search Result

Gene Information

Gene Name	DHFR
Gene ID	1719
Gene Full Name	dihydrofolate reductase
Gene Alias	DYR; DHFRP1
Transcripts	ENSG00000228716
Virus	HIV
Gene Type	protein coding
HPA Location Info	Mitochondria;
HPA Protein Class Info	Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Predicted intracellular proteins
Uniport_ID	P00374
HGNC ID	HGNC:2861
VEGA ID	OTTHUMG00000162529
OMIM ID	126060
String ID	9606.ENSP00000396308
Drugbank ID	BE0000330; BE0010403; BE0009974
PharmGKB ID	PA143

Target gene [DHFR] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4010750	chr5	7	1		8	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of DHFR expression and immune infiltrating cell level correlation result in HIV+ samples
DHFR expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of DHFR expression and immune infiltrating cell level correlation result in HIV+ samples
DHFR expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).