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HIV Target gene Detail Information

> DGKE Gene Search Result


Gene Information
Gene Name DGKE
Gene ID 8526
Gene Full Name diacylglycerol kinase epsilon
Gene Alias DGK; AHUS7; DAGK5; DAGK6; NPHS7
Transcripts ENSG00000153933
Virus HIV
Gene Type protein coding
HPA Location Info Cytosol;Nucleoplasm;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID P52429
HGNC ID HGNC:2852
VEGA ID OTTHUMG00000178121
OMIM ID 601440
String ID 9606.ENSP00000284061
Drugbank ID BE0010298; BE0009935
PharmGKB ID PA27313
Target gene [DGKE] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
4004413 chr17 25 8 11 44 View
4007257 chr17 3 15 2 20 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE17372 (GEO) AIDS-associated lymphoma 17 AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO) HIV-infected disease 44 HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372

HeatMap of cell type fractions in all samples Lollipop of DGKE expression and immune infiltrating cell level correlation result in HIV+ samples
DGKE expression: Low -> High

> Dataset: GSE50834

HeatMap of cell type fractions in all samples Lollipop of DGKE expression and immune infiltrating cell level correlation result in HIV+ samples
DGKE expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).