HIV Target gene Detail Information

> DET1 Gene Search Result

Gene Information

Gene Name	DET1
Gene ID	55070
Gene Full Name	DET1, COP1 ubiquitin ligase partner
Transcripts	ENSG00000140543
Virus	HIV
Gene Type	protein coding
HPA Location Info	Microtubules;Nucleoplasm;Cytokinetic bridge;Cytosol;
HPA Protein Class Info	Predicted intracellular proteins
Uniport_ID	Q7L5Y6
HGNC ID	HGNC:25477
VEGA ID	OTTHUMG00000171851
OMIM ID	608727
String ID	9606.ENSP00000456340
PharmGKB ID	PA134943899

Target gene [DET1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4005653	chr15	18	9	3	30	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of DET1 expression and immune infiltrating cell level correlation result in HIV+ samples
DET1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of DET1 expression and immune infiltrating cell level correlation result in HIV+ samples
DET1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).