HIV Target gene Detail Information

> DET1 Gene Search Result


Gene Information
Gene Name DET1
Gene ID 55070
Gene Full Name DET1, COP1 ubiquitin ligase partner
Transcripts ENSG00000140543
Virus HIV
Gene Type protein coding
HPA Location Info Microtubules;Nucleoplasm;Cytokinetic bridge;Cytosol;
HPA Protein Class Info Predicted intracellular proteins
Uniport_ID Q7L5Y6
HGNC ID HGNC:25477
VEGA ID OTTHUMG00000171851
OMIM ID 608727
String ID 9606.ENSP00000456340
PharmGKB ID PA134943899
Target gene [DET1] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
4005653 chr15 18 9 3 30 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE17372 (GEO) AIDS-associated lymphoma 17 AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO) HIV-infected disease 44 HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372

HeatMap of cell type fractions in all samples Lollipop of DET1 expression and immune infiltrating cell level correlation result in HIV+ samples
DET1 expression: Low -> High

> Dataset: GSE50834

HeatMap of cell type fractions in all samples Lollipop of DET1 expression and immune infiltrating cell level correlation result in HIV+ samples
DET1 expression: Low -> High

Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).