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HPV Target gene Detail Information

> DEFB136 Gene Search Result


Gene Information
Gene Name DEFB136
Gene ID 613210
Gene Full Name defensin beta 136
Gene Alias DEFB137
Transcripts ENSG00000285087
Virus HPV
Gene Type protein coding
HPA Location Info
HPA Protein Class Info Predicted secreted proteins
Uniport_ID Q30KP8
HGNC ID HGNC:34433
VEGA ID OTTHUMG00000158720
String ID 9606.ENSP00000371644
PharmGKB ID PA165585543
Target gene [DEFB136] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
5404808 chr8 5 2 7 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE140662 (GEO) Condyloma Acuminatum 8 Condyloma acuminata (HPV+)(5), Skin(3)
GSE55546 (GEO) Oropharyngeal squamous cell carcinoma 16 Oropharyngeal cancers (HPV+)(12), Normal (4)
GSE55544 (GEO) Oropharyngeal squamous cell carcinoma 23 Oropharyngeal cancers HPV Active (11), Oropharyngeal cancers HPV Inactive (4), Oropharyngeal cancers HPV Negative (8)
GSE55542 (GEO) Oropharyngeal squamous cell carcinoma 36 Oropharyngeal cancers HPV Active (12), Oropharyngeal cancers HPV Inactive (8), Oropharyngeal cancers HPV Negative (16)
HNSC (TCGA) Head and Neck squamous cell carcinoma 566 Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE140662

HeatMap of cell type fractions in all samples Lollipop of DEFB136 expression and immune infiltrating cell level correlation result in HPV+ samples
DEFB136 expression: Low -> High

> Dataset: GSE55546

HeatMap of cell type fractions in all samples Lollipop of DEFB136 expression and immune infiltrating cell level correlation result in HPV+ samples
DEFB136 expression: Low -> High

> Dataset: GSE55544

HeatMap of cell type fractions in all samples Lollipop of DEFB136 expression and immune infiltrating cell level correlation result in HPV+ samples
DEFB136 expression: Low -> High

> Dataset: GSE55542

HeatMap of cell type fractions in all samples Lollipop of DEFB136 expression and immune infiltrating cell level correlation result in HPV+ samples
DEFB136 expression: Low -> High

> Dataset: HNSC

HeatMap of cell type fractions in all samples Lollipop of DEFB136 expression and immune infiltrating cell level correlation result in HPV+ samples
DEFB136 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).