HTLV1 Target gene Detail Information

> DEFB134 Gene Search Result

Gene Information

Gene Name	DEFB134
Gene ID	613211
Gene Full Name	defensin beta 134
Transcripts	ENSG00000284754
Virus	HTLV1
Gene Type	protein coding
HPA Location Info
HPA Protein Class Info	Predicted secreted proteins
Uniport_ID	Q4QY38
HGNC ID	HGNC:32399
VEGA ID	OTTHUMG00000158718
String ID	9606.ENSP00000435010
PharmGKB ID	PA164718735

Target gene [DEFB134] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6012192	chr8	23			23	View
6030038	chr8	1			1	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of DEFB134 expression and immune infiltrating cell level correlation result in HTLV1+ samples
DEFB134 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of DEFB134 expression and immune infiltrating cell level correlation result in HTLV1+ samples
DEFB134 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of DEFB134 expression and immune infiltrating cell level correlation result in HTLV1+ samples
DEFB134 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).