HBV Target gene Detail Information

> DEFA1B Gene Search Result

Gene Information

Gene Name	DEFA1B
Gene ID	728358
Gene Full Name	defensin alpha 1B
Gene Alias	HP1; HP-1; HNP-1
Transcripts	ENSG00000285176
Virus	HBV
Gene Type	protein coding
HPA Location Info
HPA Protein Class Info	Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Transporters
Uniport_ID	P59665
HGNC ID	HGNC:33596
VEGA ID	OTTHUMG00000149850
String ID	9606.ENSP00000372136
PharmGKB ID	PA165585475

Target gene [DEFA1B] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1403463	chr8	25			25	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of DEFA1B expression and immune infiltrating cell level correlation result in HBV+ samples
DEFA1B expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).