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HBV Target gene Detail Information

> DDX18 Gene Search Result


Gene Information
Gene Name DDX18
Gene ID 8886
Gene Full Name DEAD-box helicase 18
Gene Alias Has1; MrDb
Transcripts ENSG00000088205
Virus HBV
Gene Type protein coding
HPA Location Info Mitotic chromosome;Nucleoli;Nucleoli rim;
HPA Protein Class Info Enzymes, Plasma proteins, Predicted intracellular proteins
Uniport_ID Q9NVP1
HGNC ID HGNC:2741
VEGA ID OTTHUMG00000058521
OMIM ID 606355
String ID 9606.ENSP00000263239
PharmGKB ID PA27207
Target gene [DDX18] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1000860 chr2 7 648 680 1335 View
1003440 chr2 10 112 12 134 View
1006518 chr2 37 37 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of DDX18 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
DDX18 expression: Low -> High
Lollipop of DDX18 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of DDX18 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of DDX18 expression and immune infiltrating cell level correlation result in HBV+ samples
DDX18 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).