HIV Target gene Detail Information

> DDR2 Gene Search Result

Gene Information

Gene Name	DDR2
Gene ID	4921
Gene Full Name	discoidin domain receptor tyrosine kinase 2
Gene Alias	TKT; MIG20a; NTRKR3; TYRO10
Transcripts	ENSG00000162733
Virus	HIV
Gene Type	protein coding
HPA Location Info	Actin filaments;Plasma membrane;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins
Gene Function	Suppressor gene
Uniport_ID	Q16832
HGNC ID	HGNC:2731
VEGA ID	OTTHUMG00000034423
OMIM ID	191311
String ID	9606.ENSP00000356899
Rfam ID	RF01569
Drugbank ID	BE0004741
PharmGKB ID	PA27196

Target gene [DDR2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4013834	chr1	2	1		3	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of DDR2 expression and immune infiltrating cell level correlation result in HIV+ samples
DDR2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).