HTLV1 Target gene Detail Information

> CYP51A1 Gene Search Result

Gene Information

Gene Name	CYP51A1
Gene ID	1595
Gene Full Name	cytochrome P450 family 51 subfamily A member 1
Gene Alias	LDM; CP51; CYP51; CYPL1; P450L1; P450-14DM
Transcripts	ENSG00000001630
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Endoplasmic reticulum;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Enzymes, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	Q16850
HGNC ID	HGNC:2649
VEGA ID	OTTHUMG00000131131
OMIM ID	601637
String ID	9606.ENSP00000003100
Drugbank ID	BE0000875
PharmGKB ID	PA27123

Target gene [CYP51A1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6020775	chr7	5	1		6	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of CYP51A1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
CYP51A1 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of CYP51A1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
CYP51A1 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of CYP51A1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
CYP51A1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).