HIV Target gene Detail Information

> CYLD Gene Search Result

Gene Information

Gene Name	CYLD
Gene ID	1540
Gene Full Name	CYLD lysine 63 deubiquitinase
Gene Alias	EAC; MFT; SBS; TEM; BRSS; CDMT; MFT1; CYLD1; CYLDI; USPL2
Transcripts	ENSG00000083799
Virus	HIV
Gene Type	protein coding
HPA Location Info	Centriolar satellite;Nucleoplasm;
HPA Protein Class Info	Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Gene Function	Suppressor gene
Uniport_ID	Q9NQC7
HGNC ID	HGNC:2584
VEGA ID	OTTHUMG00000173404
OMIM ID	605018
String ID	9606.ENSP00000392025
PharmGKB ID	PA27084

Target gene [CYLD] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4002969	chr16	69	2	2	73	View
4003506	chr16	60			60	View
4004464	chr16	44			44	View
4005520	chr16	11	1	20	32	View
4012071	chr16	5			5	View
4012244	chr16	5			5	View
4012586	chr16	3	2		5	View
4013307	chr16		4		4	View
4016723	chr16				0	View
4100015	chr16	31			31	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of CYLD expression and immune infiltrating cell level correlation result in HIV+ samples
CYLD expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of CYLD expression and immune infiltrating cell level correlation result in HIV+ samples
CYLD expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).